Selective human serum albumin sensor from the screening of a fluorescent rosamine library.

نویسندگان

  • Young-Hoon Ahn
  • Jun-Seok Lee
  • Young-Tae Chang
چکیده

A fluorescent dye library approach for the development of a bioanalyte sensor was sought. The screening of a rosamine dye library against diverse macromolecules led to the discovery of a highly sensitive human serum albumin binder, G13, with approximately 36-fold fluorescence intensity change. G13 showed a highly selective response to HSA over other macromolecules including albumins from other species. The potential use of G13 for the detection of HSA in biofluids is described.

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عنوان ژورنال:
  • Journal of combinatorial chemistry

دوره 10 3  شماره 

صفحات  -

تاریخ انتشار 2008